Metabolic / GLP-1

Semaglutide: reference

GLP-1 receptor agonist for type 2 diabetes (Ozempic, Rybelsus) and chronic weight management (Wegovy).

Regulatory statusFDA-Approved (labeled use)

Published half-life~7 days

Evidence levelFDA label

CategoryMetabolic / GLP-1

Regulatory status

FDA-Approved (labeled use). FDA-approved for its labeled indications. Compounded and research-grade semaglutide is not the approved product.

Reported cautions

⚠ Worth knowing. Boxed warning for thyroid C-cell tumors (rodent data); contraindicated with a personal or family history of medullary thyroid carcinoma or MEN 2. GI effects are dose-related and are the most common reason for stopping.

Pharmacokinetics

Published figures give an elimination half-life of ~7 days. FDA label (Ozempic/Wegovy): supports once-weekly dosing.

This figure is tagged FDA label in our evidence system. This figure appears in an approved product's prescribing information, which is the strongest tier in our system: a regulator-reviewed number for a specific approved product. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose or frequency information. That is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Semaglutide FDA-approved?

FDA-Approved (labeled use). FDA-approved for its labeled indications. Compounded and research-grade semaglutide is not the approved product.

What is the half-life of Semaglutide?

Published figures give ~7 days. FDA label (Ozempic/Wegovy): supports once-weekly dosing.

How reliable is that half-life figure?

It is tagged “FDA label” in our system. This figure appears in an approved product's prescribing information, which is the strongest tier in our system: a regulator-reviewed number for a specific approved product.

What cautions are associated with Semaglutide?

Boxed warning for thyroid C-cell tumors (rodent data); contraindicated with a personal or family history of medullary thyroid carcinoma or MEN 2. GI effects are dose-related and are the most common reason for stopping.

Does Peptide Plug publish dosing for Semaglutide?

No. This library publishes regulatory status, general context and pharmacokinetics only. Dose and frequency information is deliberately absent from these public pages. Those are clinical decisions, not reference data.

Does Peptide Plug sell Semaglutide?

No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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If your clinician has given you a schedule, you can record it in Peptide Plug's Schedule Builder. Peptide Plug does not publish, sell or pre-fill doses, frequencies or durations for any compound.

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Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Tracking tool, not medical advice. Peptide Plug is an organization and calculation tool for adults 18 and older. It does not provide medical advice, diagnosis or treatment, and it does not recommend, suggest or verify any substance, amount, schedule or route. Calculators only perform arithmetic on the numbers you enter; double-check every result. Many compounds referenced on this site are not FDA-approved for human use, and products sold outside an approved supply chain are not verified for identity, purity or concentration. Peptide Plug does not sell, supply, source or link to sellers of any compound. Confirm every decision with a licensed clinician or pharmacist. In an emergency, call 911.

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