Semaglutide, tirzepatide and related compounds are typically titrated up through a fixed sequence of doses. Pick a compound to load its published dose ladder as quick-select buttons, then get the draw volume and syringe units for your specific vial. Planning the full titration schedule instead? See the GLP-1 Titration Planner.
Reconstitution & dose calculator
A one-off calculation — nothing here is saved or sent anywhere.
These are commonly published labeled/trial dose steps, shown for reference only — not a recommendation. Tap one to fill the dose field, or enter your own.
How to Use This Calculator
Pick a compound first — it loads the reference dose steps published for that specific molecule.
Select your compoundSemaglutide, tirzepatide, retatrutide and cagrilintide each have their own labeled or trial dose ladder — selecting one loads the right reference steps.
Enter your vial size and BAC waterCheck your vial label for total mg, and confirm how much bacteriostatic water you're adding (or plan to add).
Tap a dose step, or enter your ownThe quick-select chips show commonly published dose amounts for that compound — tap one to fill the dose field, or type any value.
Read your draw volume and syringe unitsThe result updates instantly, along with the vial's total concentration.
How the Math Works & Where the Dose Steps Come From
Vial math is the same concentration/draw-volume calculation used across this site. Reference dose steps are pulled directly from FDA prescribing information where a compound is approved, or from published clinical-trial dosing where it's investigational.
Concentration. Concentration (mg/mL) = total peptide in the vial (mg) ÷ bacteriostatic water added (mL). Standard reconstitution arithmetic.
Draw volume and syringe units. Draw volume (mL) = desired dose (mg) ÷ concentration (mg/mL). Syringe units = draw volume × the syringe's units-per-mL rating. ISO 7864 syringe graduation standards.
Semaglutide dose steps. 0.25mg, 0.5mg, 1mg, 1.7mg and 2.4mg reflect the FDA-labeled dose-escalation schedule for semaglutide (Ozempic/Wegovy). FDA prescribing information, Ozempic and Wegovy labels.
Tirzepatide dose steps. 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg and 15mg reflect the FDA-labeled dose-escalation schedule for tirzepatide (Mounjaro/Zepbound). FDA prescribing information, Mounjaro and Zepbound labels.
Retatrutide and cagrilintide dose steps. These compounds are not FDA-approved; the reference steps shown reflect dose levels studied in published Phase 2/3 clinical trials, not an approved label. Trial protocols continue to evolve as research progresses. Published Phase 2/3 clinical trial dosing protocols for retatrutide and cagrilintide.
Estimate only — not medical advice. Reference dose steps are shown for educational context only — they reflect what has been studied or labeled for an FDA-approved product, not a recommendation for your situation. GLP-1 dose escalation is individualized and should be directed by a licensed prescriber based on tolerability and clinical response, not a fixed schedule.
Frequently Asked Questions
Why does the dose ladder matter for GLP-1 medications?
GLP-1 receptor agonists are dosed on a gradual escalation schedule specifically to reduce gastrointestinal side effects like nausea, which are common when starting at a higher dose. The FDA-labeled schedules for semaglutide and tirzepatide reflect the dosing studied in the clinical trials that supported their approval.
Are retatrutide and cagrilintide FDA-approved?
No — as of this writing, both are investigational compounds still in clinical trials. The dose steps shown for them reflect published trial protocols, not an approved labeled dose, and that status can change as trials progress. Always verify current regulatory status directly.
Can I use this for a compounded GLP-1 product?
The reconstitution math works for any vial regardless of source, but the reference dose steps reflect the branded, FDA-labeled products specifically. Compounded formulations can vary in concentration and are not evaluated by the FDA the same way — verify your specific product's labeling independently.
How long should I stay on one dose before increasing?
FDA labels for semaglutide and tirzepatide specify minimum intervals (commonly four weeks) before a dose increase, based on the trial protocols. This is a prescriber decision based on tolerability, not something this calculator determines.
What if my vial size doesn't match a common preset?
Enter your vial's actual mg content and BAC water amount directly — the dose-step chips are just a convenience for the dose field, and the vial math itself works with any numbers you enter.
Does this tool tell me which dose I should be on?
No. It converts a dose you specify (or select from the reference list) into a draw volume and syringe units. Deciding which dose is appropriate for you is a clinical decision between you and your prescriber.
What's the difference between this and the GLP-1 Titration Planner?
This tool calculates the vial math for a single dose at a time. The GLP-1 Titration Planner lays out an entire multi-week escalation schedule with dates, for planning ahead.
Can I use this for a blended GLP-1 product, like a cagrilintide/semaglutide combination?
This tool assumes a single compound's concentration. For a blend with more than one active compound in the same vial, use the full Reconstitution Calculator, which has dedicated per-compound blend math.
Does this tool save or send my numbers anywhere?
No — everything runs locally in your browser. To log your actual dose history, inventory and cost-per-dose over time, see the full Peptide Plug app.
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