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Reference only · Not medical advice · For adults 18+ · No dosing information is published here
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Home/Research library/Cagrilintide / Semaglutide Blend
Metabolic / GLP-1

Cagrilintide / Semaglutide Blend — reference

Fixed weekly combination of an amylin analog and a GLP-1 agonist (CagriSema), studied for weight management.

Regulatory statusInvestigational
Published half-lifeReflects both components (~7d cagrilintide, ~7d semaglutide)
Evidence levelClinical trial
CategoryMetabolic / GLP-1

Regulatory status

Investigational. Not FDA-approved. Novo Nordisk has filed an NDA with the FDA and it was under review at the time of writing — verify current status.

Reported cautions

⚠ Worth knowing. Compounded or research-grade 'cagri-sema' is not the trial formulation, and its ratio is frequently different. Model each component separately rather than assuming the trial ratio.

Pharmacokinetics

Published figures give an elimination half-life of Reflects both components (~7d cagrilintide, ~7d semaglutide). Combination behaves pharmacokinetically as two independent long-acting agents.

This figure is tagged Clinical trial in our evidence system. This figure comes from published human trial data rather than an approved label. It is real data, but it has not been through regulatory review, and the compound may not be approved for any use. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose, frequency or cycle information — that is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Cagrilintide / Semaglutide Blend FDA-approved?
Investigational. Not FDA-approved. Novo Nordisk has filed an NDA with the FDA and it was under review at the time of writing — verify current status.
What is the half-life of Cagrilintide / Semaglutide Blend?
Published figures give Reflects both components (~7d cagrilintide, ~7d semaglutide). Combination behaves pharmacokinetically as two independent long-acting agents.
How reliable is that half-life figure?
It is tagged “Clinical trial” in our system. This figure comes from published human trial data rather than an approved label. It is real data, but it has not been through regulatory review, and the compound may not be approved for any use.
What cautions are associated with Cagrilintide / Semaglutide Blend?
Compounded or research-grade 'cagri-sema' is not the trial formulation, and its ratio is frequently different. Model each component separately rather than assuming the trial ratio.
Does Peptide Plug publish dosing for Cagrilintide / Semaglutide Blend?
No. This library publishes regulatory status, general context and pharmacokinetics only. Dose, frequency and cycle information is deliberately absent from these public pages — those are clinical decisions, not reference data.
Does Peptide Plug sell Cagrilintide / Semaglutide Blend?
No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Part of the Peptide Plug research library · How we source our figures