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Reference only · Not medical advice · For adults 18+ · No dosing information is published here
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SERMs

Tamoxifen (Nolvadex) — reference

SERM approved for breast cancer treatment and risk reduction; used off-label for gynecomastia and post-cycle contexts.

Regulatory statusFDA-Approved (labeled use)
Published half-life~5–7 days (parent); active metabolite endoxifen ~4–11 days
Evidence levelFDA label
CategorySERMs

Regulatory status

FDA-Approved (labeled use). FDA-approved for breast cancer indications. Use for gynecomastia or hormonal recovery in men is off-label.

Reported cautions

⚠ Worth knowing. Carries a boxed warning for uterine malignancies, stroke and pulmonary embolism in the risk-reduction population. Not a benign accessory drug.

Pharmacokinetics

Published figures give an elimination half-life of ~5–7 days (parent); active metabolite endoxifen ~4–11 days. FDA label; steady state takes weeks due to long metabolite half-life.

This figure is tagged FDA label in our evidence system. This figure appears in an approved product's prescribing information, which is the strongest tier in our system — a regulator-reviewed number for a specific approved product. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose, frequency or cycle information — that is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Tamoxifen (Nolvadex) FDA-approved?
FDA-Approved (labeled use). FDA-approved for breast cancer indications. Use for gynecomastia or hormonal recovery in men is off-label.
What is the half-life of Tamoxifen (Nolvadex)?
Published figures give ~5–7 days (parent); active metabolite endoxifen ~4–11 days. FDA label; steady state takes weeks due to long metabolite half-life.
How reliable is that half-life figure?
It is tagged “FDA label” in our system. This figure appears in an approved product's prescribing information, which is the strongest tier in our system — a regulator-reviewed number for a specific approved product.
What cautions are associated with Tamoxifen (Nolvadex)?
Carries a boxed warning for uterine malignancies, stroke and pulmonary embolism in the risk-reduction population. Not a benign accessory drug.
Does Peptide Plug publish dosing for Tamoxifen (Nolvadex)?
No. This library publishes regulatory status, general context and pharmacokinetics only. Dose, frequency and cycle information is deliberately absent from these public pages — those are clinical decisions, not reference data.
Does Peptide Plug sell Tamoxifen (Nolvadex)?
No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Part of the Peptide Plug research library · How we source our figures