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Peptide Plug is a research and organization tool intended for adults 18 years of age or older. By continuing, you confirm you are at least 18.

Reference only · Not medical advice · For adults 18+ · No dosing information is published here
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Growth Hormone

Sermorelin — reference

GHRH analog, historically FDA-approved (Geref, now discontinued) and still compounded/prescribed off-label for GH support.

Regulatory statusNot FDA-Approved
Published half-life~10–20 minutes
Evidence levelPK study
CategoryGrowth Hormone

Regulatory status

Not FDA-Approved. No longer marketed as an FDA-approved product; typically obtained via a compounding pharmacy prescription.

Reported cautions

⚠ Worth knowing. Requires an intact pituitary to have any effect. The original US product is discontinued, so current supply is compounded rather than FDA-approved. Banned by WADA.

Pharmacokinetics

Published figures give an elimination half-life of ~10–20 minutes. GHRH(1-29) fragment; rapidly degraded, consistent with native GHRH's own short half-life.

This figure is tagged PK study in our evidence system. This figure comes from a published pharmacokinetic study rather than a label or registration trial. Sample sizes in such studies are often small and figures vary between them, so treat the number as a range rather than a constant. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose, frequency or cycle information — that is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Sermorelin FDA-approved?
Not FDA-Approved. No longer marketed as an FDA-approved product; typically obtained via a compounding pharmacy prescription.
What is the half-life of Sermorelin?
Published figures give ~10–20 minutes. GHRH(1-29) fragment; rapidly degraded, consistent with native GHRH's own short half-life.
How reliable is that half-life figure?
It is tagged “PK study” in our system. This figure comes from a published pharmacokinetic study rather than a label or registration trial. Sample sizes in such studies are often small and figures vary between them, so treat the number as a range rather than a constant.
What cautions are associated with Sermorelin?
Requires an intact pituitary to have any effect. The original US product is discontinued, so current supply is compounded rather than FDA-approved. Banned by WADA.
Does Peptide Plug publish dosing for Sermorelin?
No. This library publishes regulatory status, general context and pharmacokinetics only. Dose, frequency and cycle information is deliberately absent from these public pages — those are clinical decisions, not reference data.
Does Peptide Plug sell Sermorelin?
No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Part of the Peptide Plug research library · How we source our figures