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Reference only · Not medical advice · For adults 18+ · No dosing information is published here
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Cognitive / Neuro

Semax — reference

A fragment of ACTH modified to remove hormonal activity, used in Russia for stroke recovery and cognitive indications.

Regulatory statusNot FDA-Approved
Published half-life~30 minutes (intranasal)
Evidence levelLimited data
CategoryCognitive / Neuro

Regulatory status

Not FDA-Approved. Approved as a medication in Russia; not FDA-approved and not an approved dietary ingredient in the US.

Reported cautions

⚠ Worth knowing. Nearly all clinical literature is Russian-language and has not been independently replicated in Western trials. Spray strength varies by supplier.

Pharmacokinetics

Published figures give an elimination half-life of ~30 minutes (intranasal). Mostly Russian-language clinical literature; limited independent replication.

This figure is tagged Limited data in our evidence system. The available data does not support a confident single figure, so this entry is flagged accordingly. Read any curve built from it as illustrative only. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose, frequency or cycle information — that is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Semax FDA-approved?
Not FDA-Approved. Approved as a medication in Russia; not FDA-approved and not an approved dietary ingredient in the US.
What is the half-life of Semax?
Published figures give ~30 minutes (intranasal). Mostly Russian-language clinical literature; limited independent replication.
How reliable is that half-life figure?
It is tagged “Limited data” in our system. The available data does not support a confident single figure, so this entry is flagged accordingly. Read any curve built from it as illustrative only.
What cautions are associated with Semax?
Nearly all clinical literature is Russian-language and has not been independently replicated in Western trials. Spray strength varies by supplier.
Does Peptide Plug publish dosing for Semax?
No. This library publishes regulatory status, general context and pharmacokinetics only. Dose, frequency and cycle information is deliberately absent from these public pages — those are clinical decisions, not reference data.
Does Peptide Plug sell Semax?
No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Part of the Peptide Plug research library · How we source our figures