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Reference only · Not medical advice · For adults 18+ · No dosing information is published here
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GH Secretagogues

Mk-677 (Ibutamoren) — reference

Orally active non-peptide ghrelin-receptor agonist that raises GH and IGF-1.

Regulatory statusNot FDA-Approved
Published half-life~24 hours
Evidence levelPK study
CategoryGH Secretagogues

Regulatory status

Not FDA-Approved. Never FDA-approved despite completing multiple clinical trials. Sold widely as a “research chemical” or mislabelled as a supplement. Banned by WADA.

Reported cautions

⚠ Worth knowing. Reliably increases appetite, water retention and — importantly — reduces insulin sensitivity, with fasting glucose rises documented in trials. A trial in elderly patients with hip fracture was noted for increased congestive heart failure events.

Pharmacokinetics

Published figures give an elimination half-life of ~24 hours. Long for a GH secretagogue — the reason it's dosed once daily and is orally active.

This figure is tagged PK study in our evidence system. This figure comes from a published pharmacokinetic study rather than a label or registration trial. Sample sizes in such studies are often small and figures vary between them, so treat the number as a range rather than a constant. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose, frequency or cycle information — that is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Mk-677 (Ibutamoren) FDA-approved?
Not FDA-Approved. Never FDA-approved despite completing multiple clinical trials. Sold widely as a “research chemical” or mislabelled as a supplement. Banned by WADA.
What is the half-life of Mk-677 (Ibutamoren)?
Published figures give ~24 hours. Long for a GH secretagogue — the reason it's dosed once daily and is orally active.
How reliable is that half-life figure?
It is tagged “PK study” in our system. This figure comes from a published pharmacokinetic study rather than a label or registration trial. Sample sizes in such studies are often small and figures vary between them, so treat the number as a range rather than a constant.
What cautions are associated with Mk-677 (Ibutamoren)?
Reliably increases appetite, water retention and — importantly — reduces insulin sensitivity, with fasting glucose rises documented in trials. A trial in elderly patients with hip fracture was noted for increased congestive heart failure events.
Does Peptide Plug publish dosing for Mk-677 (Ibutamoren)?
No. This library publishes regulatory status, general context and pharmacokinetics only. Dose, frequency and cycle information is deliberately absent from these public pages — those are clinical decisions, not reference data.
Does Peptide Plug sell Mk-677 (Ibutamoren)?
No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Part of the Peptide Plug research library · How we source our figures