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Reference only · Not medical advice · For adults 18+ · No dosing information is published here
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Skin, Hair & Pigmentation

Melanotan Ii — reference

A more potent, less selective melanocortin analogue used non-medically for tanning, with incidental effects on appetite and erectile function.

Regulatory statusNot FDA-Approved
Published half-life~30–45 minutes
Evidence levelLimited data
CategorySkin, Hair & Pigmentation

Regulatory status

Not FDA-Approved. Not approved anywhere for human use. Regulators in several countries have issued warnings against it.

Reported cautions

⚠ Worth knowing. Case reports link it to changing or new melanocytic lesions and to melanoma, and to priapism from its melanocortin activity. Nausea and facial flushing after dosing are common. Existing moles darkening is a documented effect and a reason for dermatological review.

Pharmacokinetics

Published figures give an elimination half-life of ~30–45 minutes. Not FDA-approved; figures come from small PK studies and vendor literature.

This figure is tagged Limited data in our evidence system. The available data does not support a confident single figure, so this entry is flagged accordingly. Read any curve built from it as illustrative only. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose, frequency or cycle information — that is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Melanotan Ii FDA-approved?
Not FDA-Approved. Not approved anywhere for human use. Regulators in several countries have issued warnings against it.
What is the half-life of Melanotan Ii?
Published figures give ~30–45 minutes. Not FDA-approved; figures come from small PK studies and vendor literature.
How reliable is that half-life figure?
It is tagged “Limited data” in our system. The available data does not support a confident single figure, so this entry is flagged accordingly. Read any curve built from it as illustrative only.
What cautions are associated with Melanotan Ii?
Case reports link it to changing or new melanocytic lesions and to melanoma, and to priapism from its melanocortin activity. Nausea and facial flushing after dosing are common. Existing moles darkening is a documented effect and a reason for dermatological review.
Does Peptide Plug publish dosing for Melanotan Ii?
No. This library publishes regulatory status, general context and pharmacokinetics only. Dose, frequency and cycle information is deliberately absent from these public pages — those are clinical decisions, not reference data.
Does Peptide Plug sell Melanotan Ii?
No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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Pro Protocol Reference

The public research page intentionally does not publish dosing. Pro subscribers can open the separate Protocol Library for structured indication, frequency, duration, notes, and review-first Cycle Builder import when a matching reference is available.

View Protocol Reference
Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Part of the Peptide Plug research library · How we source our figures · All compounds A–Z