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Reference only · Not medical advice · For adults 18+ · No dosing information is published here
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Skin, Hair & Pigmentation

Argireline — reference

Acetyl hexapeptide-8, a widely used cosmetic peptide marketed for the appearance of expression lines.

Regulatory statusMixed Regulatory Status
Published half-lifeNot applicable — topical cosmetic peptide
Evidence levelNot characterised
CategorySkin, Hair & Pigmentation

Regulatory status

Mixed Regulatory Status. A cosmetic ingredient, not an FDA-approved drug.

Reported cautions

⚠ Worth knowing. Skin penetration of a hexapeptide is limited, which is the main scientific objection to the mechanism claimed for it. Manufacturer-funded studies dominate the evidence.

Pharmacokinetics

Not applicable — topical cosmetic peptide. —

This figure is tagged Not characterised in our evidence system. No reliable human pharmacokinetic data was found for this compound. We publish that fact rather than a number borrowed from an unreliable source. Any estimated curve here would be fiction, and should be treated as such. You can see the shape this implies between doses in the Half-Life Visualizer, and compare it against every other compound in the Half-Life Data Table. Our sourcing page explains what each tier means.

Remember that an estimated curve is a model built from a population figure, not a measurement of your blood. Individual clearance varies, and for depot injections the figure describes release from the injection site rather than the compound clearing. Half-life explained →

What Peptide Plug does and does not publish

This page carries regulatory status, general context and published pharmacokinetics. It carries no dose, frequency or cycle information — that is a deliberate editorial line, because dosing is a clinical decision rather than reference data. We also do not sell, supply, source or link to vendors for any compound.

Frequently asked

Is Argireline FDA-approved?
Mixed Regulatory Status. A cosmetic ingredient, not an FDA-approved drug.
What is the half-life of Argireline?
Published figures give Not applicable — topical cosmetic peptide. —
How reliable is that half-life figure?
It is tagged “Not characterised” in our system. No reliable human pharmacokinetic data was found for this compound. We publish that fact rather than a number borrowed from an unreliable source. Any estimated curve here would be fiction, and should be treated as such.
What cautions are associated with Argireline?
Skin penetration of a hexapeptide is limited, which is the main scientific objection to the mechanism claimed for it. Manufacturer-funded studies dominate the evidence.
Does Peptide Plug publish dosing for Argireline?
No. This library publishes regulatory status, general context and pharmacokinetics only. Dose, frequency and cycle information is deliberately absent from these public pages — those are clinical decisions, not reference data.
Does Peptide Plug sell Argireline?
No. We do not sell, supply, source or link to vendors for any compound, and we have no affiliate arrangements with suppliers. Peptide Plug is a tracking and calculation tool.

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Reference information, not medical advice. This page describes regulatory status and published pharmacokinetics. It does not tell you whether to use this compound, how much to use, how often, or whether it is safe for you. Peptide Plug does not sell, supply or source any compound. Those decisions belong to you and a licensed clinician.

Part of the Peptide Plug research library · How we source our figures